Head-to-head · Best Vertical Ergonomic Mice

Keychron M5 vs Logitech MX Vertical

Which is the better buy? Side-by-side on rating, price, strengths, and watch-outs — with the published ratings we averaged to get there.

The short answer

Logitech MX Vertical comes out ahead by a narrow margin (4.4 vs 4.7). The gap is mostly about Professionals with medium-to-large hands who want the premium vertical mouse for long workdays and multi-device use. — read the strengths below before deciding.

Ranked #4 in Best Vertical Ergonomic Mice

Keychron M5

4.4

$69.99as of Jun 7

The Keychron M5 is the rare vertical mouse built for gaming as well as ergonomics, pairing a 47-degree angle with a PixArt 3950 sensor, 8000Hz polling and a light 95g body. Reviewers call it the best vertical gaming mouse they have used and praise its value. It is the pick for buyers who want wrist relief without giving up performance.

Strengths

— Gaming-grade PixArt 3950 sensor with up to 30,000 DPI and 8000Hz polling
— Lightweight 95g body, unusually light for a vertical mouse
— 47-degree vertical angle relieves wrist strain while staying usable for gaming

Watch-outs

— No silent-click option; clicks are loud
— No left-handed version available
— Less steeply vertical than dedicated ergonomic mice

$69.99 · Check Price on Amazon Full review →

Higher ratedRanked #1 in Best Vertical Ergonomic Mice

Logitech MX Vertical

4.7

$74.49as of May 29

The Logitech MX Vertical is the premium benchmark for vertical ergonomic mice, using a 57-degree handshake angle to hold the wrist in a neutral position. Reviewers praise its sculpted, high-end build and ergonomic comfort for medium-to-large hands. Its clicks are louder and it is bigger than the Lift, but it remains the gold-standard vertical mouse for serious desk work.

Strengths

— 57-degree handshake angle forces a neutral forearm position that reduces wrist strain
— Premium sculpted build with a metal scroll wheel feels high-end
— Rechargeable via USB-C with around 4 months of battery per charge

Watch-outs

— Too large for small hands; reaching the thumb buttons can be a stretch
— Loud clicks compared to the quieter Logitech Lift
— Default 125Hz polling rate feels choppy on high-refresh screens

$74.49 · Check Price on Amazon Full review →

How they stack up

Keychron M5

The Keychron M5 is the only vertical mouse here with a gaming-grade sensor and 8000Hz polling, outclassing the Logitech MX Vertical, Logitech Lift and Evoluent VerticalMouse C for performance, though its 47-degree angle is less steeply vertical than the Evoluent and it costs more than the budget Anker vertical mouse.

Logitech MX Vertical

The MX Vertical is larger and louder than the Logitech Lift, making it the better fit for big hands, and it feels more premium and is cheaper than the Evoluent VerticalMouse C, though it lacks the Keychron M5's gaming sensor and costs far more than the budget Anker vertical mouse.

Specs side-by-side

Spec	Keychron M5	Logitech MX Vertical
Vertical Angle	47 degrees	57 degrees
Sensor	PixArt 3950, up to 30000 DPI	Up to 4000 DPI
Polling Rate	Up to 8000Hz	—
Connectivity	2.4GHz, Bluetooth 5.3, USB-C wired	Bluetooth, Logi Bolt USB receiver
Battery	Up to 140 hours	Rechargeable USB-C, ~4 months
Buttons	5 programmable	6 programmable
Weight	95g	135g
Build	Lightweight	—
Hand Size	—	Medium to large
Scroll Wheel	—	Metal

← See the full ranking of best vertical ergonomic mice