Head-to-head · Best Vertical Ergonomic Mice

Anker 2.4G Wireless Vertical Ergonomic Mouse vs Keychron M5

Which is the better buy? Side-by-side on rating, price, strengths, and watch-outs — with the published ratings we averaged to get there.

The short answer

Keychron M5 comes out ahead by a narrow margin (4.3 vs 4.4). The gap is mostly about Gamers and power users who want wrist relief from a vertical mouse without sacrificing sensor performance or polling rate. — read the strengths below before deciding.

Ranked #5 in Best Vertical Ergonomic Mice

Anker 2.4G Wireless Vertical Ergonomic Mouse

4.3

$19.98as of Jun 7

The Anker 2.4G Wireless Vertical Ergonomic Mouse brings the handshake-position benefit of vertical mice to a budget price. Reviewers call it cheap, cheerful and effective, praising its comfortable soft-touch coating and value. It tops out at 1600 DPI and lacks Bluetooth, but for around $25 it is widely regarded as the best budget entry point into vertical mice.

Strengths

— Handshake-position vertical design at a budget-friendly price
— Soft, tactile coating provides comfortable, secure grip
— Three DPI settings (800/1200/1600) selectable via a dedicated button

Watch-outs

— Only up to 1600 DPI, low for high-resolution displays
— 2.4GHz only; no Bluetooth and runs on disposable AAA batteries
— Browser buttons hard to reach for small hands

$19.98 · Check Price on Amazon Full review →

Higher ratedRanked #4 in Best Vertical Ergonomic Mice

Keychron M5

4.4

$69.99as of Jun 7

The Keychron M5 is the rare vertical mouse built for gaming as well as ergonomics, pairing a 47-degree angle with a PixArt 3950 sensor, 8000Hz polling and a light 95g body. Reviewers call it the best vertical gaming mouse they have used and praise its value. It is the pick for buyers who want wrist relief without giving up performance.

Strengths

— Gaming-grade PixArt 3950 sensor with up to 30,000 DPI and 8000Hz polling
— Lightweight 95g body, unusually light for a vertical mouse
— 47-degree vertical angle relieves wrist strain while staying usable for gaming

Watch-outs

— No silent-click option; clicks are loud
— No left-handed version available
— Less steeply vertical than dedicated ergonomic mice

$69.99 · Check Price on Amazon Full review →

How they stack up

Anker 2.4G Wireless Vertical Ergonomic Mouse

The Anker vertical mouse offers the same handshake benefit as the Logitech MX Vertical, Logitech Lift and Evoluent VerticalMouse C for a fraction of the price, but it tops out at 1600 DPI, lacks Bluetooth, and cannot match the build of the Logitech mice or the gaming sensor of the Keychron M5.

Keychron M5

The Keychron M5 is the only vertical mouse here with a gaming-grade sensor and 8000Hz polling, outclassing the Logitech MX Vertical, Logitech Lift and Evoluent VerticalMouse C for performance, though its 47-degree angle is less steeply vertical than the Evoluent and it costs more than the budget Anker vertical mouse.

Specs side-by-side

Spec	Anker 2.4G Wireless Vertical Ergonomic Mouse	Keychron M5
Grip	Vertical handshake	—
Sensor	800/1200/1600 DPI optical	PixArt 3950, up to 30000 DPI
Connectivity	2.4GHz wireless receiver	2.4GHz, Bluetooth 5.3, USB-C wired
Battery	2 AAA	Up to 140 hours
Buttons	5 including next/previous	5 programmable
Weight	3.4 oz (96g)	95g
Warranty	18 months	—
Coating	Soft-touch plastic	—
Vertical Angle	—	47 degrees
Polling Rate	—	Up to 8000Hz
Build	—	Lightweight

← See the full ranking of best vertical ergonomic mice